kick off of the Op2Lysis Crowdfunding campaign on WiSEED – Fundraising #1

As a result of a long and hard work, which was led over these last months and allowed a revision of the terms negotiated for the O2L-001 license, as well as gaining non-dilutive fundings (i-LAB and loans on trust) and numerous prizes and recognitions, Op2Lysis initiated its crowdfunding campaign on the platform.

The objective of this fundraising is to fund the feasibility of the industrial production and formulation of O2L-001 over the next 12 months. At the end of this first period of our development program, we will have sufficient information on production, purification, and formulation to initiate the regulatory preclinical steps of O2L-001 development, with a compound able to liquefy an intracerebral hematoma with one single injection. Scale-up and preparation of the regulatory studies will require a second fundraising for 2019.

French–Flemish meetings with the FIT Agency

September 2017 – French-Flemish meeting with the FIT Agency in Leuven (BE)

Op2Lysis was in Leuven during the French-Flemish meetings, which were organized by Flanders Investment and Trade (FIT). Great meeting opportunities.




Prof. Denis Vivien was in Berlin for the 26th ISTH session

Prof. Denis Vivien was invited to attend ISTH (International Society on Thrombosis and Haemostasis) in Berlin (Germany) and present his lab’s experience on preclinical models of ischemic or hemorrhagic strokes. He also introduced STROKE@LLIANCE, a program that was launched to improve the translational progress of drug candidates towards clinical stage through mimicking at the preclinical lab stage the heterogeneity of early clinical phases. 

Op2Lysis is a NETVA Laureate

Op2Lysis was selected as a Laureate among 20 for NETVA 2017. This will allow us to go to BOSTON during the second part of the year to better understand the North American market (including regulations and hospital needs), as well as the biotechnology ecosystem to identify potential partners and investors.

The NETVA Press Release.


The New Technology Venture Accelerator (NETVA) is a program of preparation and exposure to high-tech US markets for young innovative French companies. It is run by the Office for Science & Technology of the Embassy of France in the United States in three locations: Boston, San Francisco and Washington, DC.

Each year, 15 French startups are selected though a national competition after evaluation by juries in France and the program’s three American cities. In 2015, the program was expanded to Canada.

The selected laureates begin their preparation for US markets with a two-day training seminar in France. Each laureate is also paired with one or more American mentors prior to an intense week of immersion in the United States. The laureates then have the opportunity to network with high-level American academic and technological partners and to benefit from an additional series of training workshops focused on how to approach and succeed in American markets.

For more information : – contact [at]

[VIDEO] Biovision 2017. Award Ceremony

A 1’26’’ video of the award ceremony. Op2Lysis received the Special Prize for its ambitious program at the Biovision Forum (Lyon, France), in April 2017. This video is also available on our Youtube Channel #Op2Lysis.


Op2Lysis won the Special Prize at Biovision Forum 2017

Op2Lysis received the “Catalyzer” Special Prize at the Biovision Forum in Lyon, France, on Thursday, April 6. Christophe Gaudin, co-founder of Op2Lysis, could convince the jury to honor Op2Lysis, based on our ambition of developing the first medical treatment for hemorrhagic stroke patients (a form which affects 10 to 15% of stroke patients), and on the potential and quality of our technology.

More information on the laureates and on the Biovision forum is available at

Op2Lysis shows successful traction after voting period on the WiSEED crowdfunding platform

A warm thank to all of you! Thanks to your positive support, your encouragements, your votes in favour, your comments and your promise to invest in our company, Op2Lysis reached the milestones to enter into the next step. An audit will now take place before the initiation of the investment phase.

We want to thank everyone who helped us in this first step. We will continue to post messages and news on the different Op2Lysis channels (LinkedIn, WiSEED and, in order to inform you as soon as the investment phase can start. With your support, we want to move forward our development program dedicated to hemorrhagic stroke patients.

Stay tuned and thanks again,

Christophe and Jérôme

Who are we? Episode #3 Jean-Claude Müller

In this mini-series of articles, we want to present you the people who contribute to Op2Lysis.

Jean-Claude, can you introduce yourself briefly ?

JCM: I am Special Advisor at I&IR (Innovation & International Relationship – BtoBio Innovation). I have more than 35 years of experience in the pharmaceutical industry, at Roche, Synthelabo and Sanofi. In my early carrier, I led research programs in the cardiology, cardiothrombosis and infectious disease areas. From 1995 I was progressively involved in research partnerships, strategic alliances, and business development for R&D, then I was in charge of R&D administration and HR. In my last role at Sanofi, I wa in charge of Prospective and Strategic Projects. I was also the Founder President of the MEDICEN Paris Region competitive cluster. I am now the editor of a weekly biopharmaceutical newsletter, which is published on At I&IR, my current responsibility is to help innovative start-ups and SMEs in defining their strategy and their international development.

What have been your main contributions to the pharmaceutical field ?

J.C.M.: During my research time, I moved a dozen of products to clinical development in the cardiology, thrombosis and infectious disease areas. I set up about twenty strategic R&D partnerships across the world. I worked on the integration of R&D teams from Sanofi and Aventis together (more than 13 000 people were involved in 21 different locations in Europe, US, and Japan). I set up the R&D structure of Sanofi in China. In 2010, I defined the 2020 R&D strategy for Sanofi-Aventis.

What is the main strength of the technology developed by Op2Lysis ?

J.C.M.: The therapeutic option that is proposed by Op2Lysis is very innovative because it is a therapy that is adapted to the needs of a potentially effective treatment for acute hemorrhagic stroke patients, with a product that has been specifically designed to get a tolerance and a pharmacokinetic profile clearly superior to other treatments, either in development or commercially available.

What is your added-value to Op2Lysis ?

J.C.M. : I am an advisor for the co-founders, Christophe Gaudin and Jérôme Parcq. My experience in international business and in strategical development are added values for them. I advise on company plans and vision , as well as on fundraising steps.

Act FAST to detect a stroke and save life

Stroke is a cardiovascular disease with severe neurological consequences. There are two main forms of stroke: the ischemic stroke, which is due to the formation of a blood clot Inside a cerebral vessel, and the hemorrhagic stroke, which is consecutive the rupture of a cerebral vessel. These two forms share the same symptoms.

Op2Lysis is currently developing the first medical treatment dedicated to hemorrhagic stroke patients. tPA-induced thrombolysis and mechanical retrieval of blood clot are now common practices for the treatment of ischemic stroke if these strategies are started with in the few hours following symptom onset.

Kniwing and being able to identify stroke symptoms is vital for stroke victims and may save life. Act FAST and share the information!

Who are we? Episode #2 Prof. Emmanuel TOUZE

In this mini-series of articles, we want to present you the people who contribute to Op2Lysis

Prof. Emmanuel TOUZE, can you introduce yourself briefly?
E.T. I am a Neurologist, working at the Hospital of Caen. I am also the Dean of the Medical School of Caen. I spent over 15 years in the Department of Neurology at several hospitals in France. Today, I am the Head of the Stroke Unit of Caen, a platform which is dedicated to the management of emergency care for stroke patients. Besides this function, I am involved in clinical research with the aim of improving the treatment of stroke patients and I also take part in networks of international experts in this field.

What is your most important contribution to stroke research?
E.T. I set up innovative tools to better understand the epidemiology of stroke and the prevention of this severe condition. These tools offer new academic research opportunities for collaborative teams [e.g., the team of Prof Denis VIVIEN at Inserm UMR-S1237, see Episode #1].

What is the main strength of the technology developed by Op2Lysis?

E.T. Op2Lysis develops a therapeutic option, which is fully suitable for an emergency unit , and which matches the needs of neurosurgeons. Their molecule has shown efficacy in preclinical studies, with the promise of an easy-to-handle solution in clinical setting [a unique injection]. Once the clinical efficacy will be proven, a fast-worldwide implementation can be expected.

What is your added-value to Op2Lysis?

E.T. I will clearly work in close collaboration with Christophe Gaudin to set up a strong clinical study protocol with the aim of getting a relevant proof of concept to strengthen and justify advanced development. There are strong expectations for the treatment of patients with an intracerebral hemorrhage, and the development, which is handled by Op2Lysis should be highly valuable.

——- Last recognitions ——-

Prof. Emmanuel Touzé is also the Secretary of the French Society of Vascular Neurology and is Assistant Editor to STROKE, a peer-reviewed journal of the American Heart Association.